What is clonoSEQ?
clonoSEQ (pronounced clo-no-seek) is the first and only FDA-cleared test that detects, counts, and tracks MRD in bone marrow samples from patients with multiple myeloma or B-cell acute lymphoblastic leukemia (B-ALL) and blood or bone marrow samples from patients with chronic lymphocytic leukemia (CLL).
Is clonoSEQ FDA approved?
The FDA cleared the clonoSEQ assay to detect and monitor minimal residual disease (MRD) in blood or bone marrow from patients with chronic lymphocytic leukemia (CLL), according to Adaptive Biotechnologies, the developer of the assay.
How much does a MRD blood test cost?
Based on previous literature, they put the cost of MRD testing at $1800 plus $1836 for specimen collection, the cost of maintenance treatment at $21,168 per month, and the cost of treatment for relapsed patients at $27,422 per month.
How do you test for MRD?
Techniques to Detect MRD
The most widely used tests are flow cytometry, polymerase chain reaction (PCR) and next-generation sequencing (NGS). These tests use samples of bone marrow cells (taken by aspiration) and/or peripheral blood cells (taken through a vein).